Objective To investigate the effects of clopidogrel resistence and CYP2C19 genotype in the clinical prognosis of intense coronary syndrome(ACS) patients undergoing percutaneous coronary intervention(PCI). Practices This study was a retrospective cohort study. ACS clients who underwent PCI in Beijing Anzhen Hospital from October 2015 to January 2017 were recruited. The inhibition rate of adenosine diphosphate(ADP) had been checked by thromboelastography. Most of these patients had been split into clopidogrel weight and non-resistance group according into the monitoring results. CYP2C19 genotype ended up being recognized by TaqMan probe-based real-time quantitative PCR. Clients had been divided into sluggish, medium and fast metabolic group, according to the CYP2C19 genotype. After 12 months of follow-up, the end things included all-cause demise, cardiac death, angina, myocardial infarction, stent thrombosis, ischemic stroke and hemorrhage were gathered. Combined thrombotic events had been thought as a composite of angina, myocardial infarctand minor hemorrhage(11.5%(54/471) vs. 15.8per cent (194/1 225), P=0.022). There were no statistically significant difference in all-cause death, cardiac death, angina, stent thrombosis, ischemic stroke and severe bleeding between clopidogrel resistance and non-resistance group(all P>0.05). There clearly was no statistically factor when you look at the incidence of endpoint activities among different CYP2C19 genotypes (all P>0.05). Cox regression evaluation showed that clopidogrel opposition ended up being an independent element of combined thrombotic events (OR=2.334, 95%CI 1.215-4.443, P=0.016) and hemorrhaging activities (OR=0.481, 95%CI 0.174-0.901, P=0.023). While CYP2C19 genotype had not been independent element for combined thrombotic activities, cardiac death and hemorrhage (all P>0.05). Conclusion For ACS customers after PCI, clopidogrel resistance can increase the risk of combined thrombotic occasions, but also lessen the risk of hemorrhaging; while CYP2C19 genotype is certainly not an independent factor for clinical prognosis.Objective To compare the prognosis of transcatheter aortic device replacement (TAVR) in clients with bicuspid aortic device (BAV) or tricuspid aortic valve (TAV) stenosis. Practices it was a retrospective study. Patients with symptomatic severe aortic stenosis, whom underwent TAVR with follow-up time one or more 12 months bio-mediated synthesis in Guangdong Provincial People’s Hospital from April 2016 to August 2018, had been included. Relating to aortic CT angiography, the clients were divided into BAV group and TAV group. The principal endpoint had been the composite occasion of all-cause death and stroke, together with secondary endpoints had been TAVR-related problems. Incidence of clinical endpoints and parameters derived from echocardiography had been contrasted between your teams, and Kaplan-Meier survival analysis had been utilized to compare the composite event between your two teams. Results a complete of 49 clients had been included. The age was (73.6±6.3) many years, and 25(51.0%) were male. There were 32 clients in BAV group and 17 in TAV team, the follow-up time had been 466 (390, 664) days. The occurrence of composite endpoint of death and stroke at one year were similar in BAV and TAV groups (6.3% (2/32) vs. 5.9% (1/17), P=1.00). Kaplan-Meier curves also showed a similar risk of the composite endpoint(HR=1.03，95%CI 0.09-11.24，Log-rank P=0.98) between two teams. The occurrence of all-cause demise, swing, myocardial infarction, significant bleeding, significant vascular problems, new-onset atrial fibrillation or atrial flutter, and permanent pacemaker implantation were all comparable amongst the two groups(all P>0.05), and there is no severe kidney injury (phase 2 or 3) in both groups. Echocardiographic parameters at one year had been similar between your two teams (all P>0.05). Conclusions The midterm prognosis of TAVR in clients with BAV and TAV stenosis is similar. Medical studies of large sample size with long-lasting followup are warranted to verify our conclusions.Objective To analyze the clinical value of left ventricular function evaluation in customers with heart disease by completely automatic quantified three-dimensional transthoracic echocardiography. Techniques One hundred and ninety-seven customers with cardiac diseases were examined by three-dimensional transthoracic echocardiography from September 2017 to May 2019. Data from 61 patients with level 1 echocardiographic picture quality were used to determine the standard boundary values of endocardial end-diastolic and end-systolic levels. Medical features were analyzed according to electronic health files. The precision and repeatability with this method was evaluated by evaluating kept ventricular end-diastolic amount (LVEDV), end-systolic volume (LVESV) and left ventricular ejection fraction (LVEF) measured by automatic quantitative three-dimensional echocardiography and the ones calculated by conventional handbook transthoracic echocardiography, the latter served as gold standard. Outcomes The levels of LVEDV, LVESV aasuring left ventricular volume and function， and it is simple for clinical application.Objective To compare the predictive value of HAS-BLED, HEMORR2HAGES, ATRIA and ORBIT results from the bleeding danger in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran. Techniques Data of 942 NVAF patients participating a non-interventional potential research Streptozotocin of anticoagulant treatment with dabigatran, that was carried out in 12 centers from February 2015 to December 2017 in Asia, had been reviewed. Complete HAS-BLED HEMORR2HAGES, ATRIA and ORBIT hemorrhaging risk results information enzyme immunoassay and follow-up data were available in the enrolled patients. The endpoint associated with study ended up being bleeding events took place during a 6 months followup. Cox proportional dangers designs were built to evaluate the associations between HAS-BLED, HEMORR2HAGES, ATRIA and ORBIT results and risk of bleeding, therefore the area underneath the bend (AUC) of receiver running faculties curves (ROC) of each score was used to create the predictive worth for bleeding threat.